Treg cells

Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

By Targets:	Apoptosis (1) Aryl Hydrocarbon Receptor (4) Autophagy (1) CCR (2) CDK (2) CTLA-4 (1) Endogenous Metabolite (5) Influenza Virus (1) Isotope-Labeled Compounds (1) Ligands for E3 Ligase (1) Molecular Glues (1) Parasite (1) RABV (1) ROR (2) STAT (4)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Endocrinology (1) Infection (1) Inflammation/Immunology (14) Metabolic Disease (1) Neurological Disease (2)
Click Chemistry:	Alkynes (1)

Targets Recommended: Nuclear Factor of activated T Cells (NFAT)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0172A

Isoallolithocholic acid 1 Publications Verification 3β-Hydroxy-5α-cholanic acid	Others	Inflammation/Immunology
Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid), a derivative of Lithocholic acid (HY-10219), is a T cell regulator. Isoallolithocholic acid enhances regulatory T cells (Tregs) differentiation .

HY-144200

CCR8 antagonist 2	CCR	Neurological Disease Cancer
CCR8 antagonist 2 is a potent antagonist of CCR8. CCR8 (C-C Motif Chemokine Receptor 8) is predominantly expressed on Treg cells and Th2 cells, but not on Th1 cells. CCR8 antagonist 2 inhibits CCR8 activity, which may be used in the research of diseases mediated by CCR8, such as cancer, and/or neuropathic pain (extracted from patent WO2022000443A1, compound 220) .

HY-P1453A

CMD178 TFA	STAT	Cancer
CMD178 TFA is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits T_reg cell development .

HY-P2520

Influenza HA (110-119)	Influenza Virus	Inflammation/Immunology
Influenza HA (110-119) is the 110-119 fragment of influenza virus hemagglutinin that can stimulate Treg cells proliferation .

HY-P1453

CMD178

STAT Cancer

CMD178 is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits T_reg cell development .

CMD178	STAT	Cancer
CMD178 is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits T_reg cell development .

HY-119217

AZ084 2 Publications Verification	CCR	Inflammation/Immunology Endocrinology
AZ084 is a potent, selective, allosteric and oral active CCR8 allosteric antagonist, with a K_i of 0.9 nM. Has potential to treat asthma . AZ084 restrains the formation of the immunologically tolerant pre-metastatic niche (PMN) and tumor cells metastasis in lung by downregulating *Treg* differentiation. AZ084 can be used in studies of asthma and cancer .

HY-N0527

Pentagalloylglucose Maximum Cited Publications 9 Publications Verification Penta-O-galloyl-β-D-glucose; 1,2,3,4,6-Pentagalloyl glucose	Parasite RABV	Infection
Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is a gallotannin isolated from various plants. It suppressed interleukin (IL)-4 induced signal pathway in B cell, and inhibited IgE production partially caused by increasing a population of Treg cells in conjunction with Treg-inducing factors. Pentagalloylglucose possesses significant anti-rabies virus (RABV) activity.

HY-B0172AS

Isoallolithocholic acid-d2 3β-Hydroxy-5α-cholanic acid-d₂	Autophagy Apoptosis Endogenous Metabolite Isotope-Labeled Compounds	Neurological Disease
Isoallolithocholic acid-d₂ is the deuterium labeled Isoallolithocholic acid (HY-B0172A). Isoallolithocholic acid is a T cell regulator and enhances regulatory T cells (Tregs) differentiation[1][2].

HY-104026B

L-Kynurenine sulfate	Endogenous Metabolite Aryl Hydrocarbon Receptor	Inflammation/Immunology
L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype .

HY-P990042

Gotistobart ONC-392; BNT 316	CTLA-4	Cancer
Gotistobart (ONC-392) is a humanized anti-CTLA-4 antibody that confers immunotherapeutic effect by selective depletion of regulatory T cells (Treg) in the tumor microenvironment .

HY-137206

ALV2	Ligands for E3 Ligase Molecular Glues	Cancer
ALV2 is a potent and selective Helios degrader. ALV2 binds CRBN, with an IC₅₀ of 0.57 μM. Helios is the zinc-finger transcription factor that can maintain a stable T_reg cell phenotype in the inflammatory tumor microenvironment .

HY-104026CS

L-Kynurenine-13C10 sulfate hemihydrate	Aryl Hydrocarbon Receptor Endogenous Metabolite	Inflammation/Immunology
L-Kynurenine- ¹³C10 (sulfate hemihydrate) is the ¹³C labeled L-Kynurenine sulfate. L-Kynurenine sulfate hemihydrate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype .

HY-162275

JMJD1C-IN-1	Others	Cancer
JMJD1C-IN-1 (compound 193D7) is an inhibitor of JMJD1C with oral activity. JMJD1C-IN-1 targets tumor Treg cells without affecting systemic immune homeostasis .

HY-104026BS

L-Kynurenine-13C10 sulfate	Aryl Hydrocarbon Receptor Endogenous Metabolite	Inflammation/Immunology
L-Kynurenine-13C10 (sulfate) is the 13C labeled L-Kynurenine sulfate. L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype .

HY-125783

1-Palmitoyl-sn-glycero-3-phosphocholine	Endogenous Metabolite	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
1-Palmitoyl-sn-glycero-3-phosphocholine is an abundant lysophosphatidylcholine. 1-Palmitoyl-sn-glycero-3-phosphocholine exhibits proinflammatory activity. 1-Palmitoyl-sn-glycero-3-phosphocholine can be used in the study of atherosclerosis .

HY-126675A

AS2863619	CDK STAT	Inflammation/Immunology
AS2863619 enables conversion of antigen-specific effector/memory T cells into Foxp3 ⁺ regulatory T (T_reg) cells for the treatment of various immunological diseases. AS2863619 is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC₅₀s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 inhibition of CDK8/19, which consequently activates the Foxp3 gene .

HY-126675

AS2863619 free base	CDK STAT	Inflammation/Immunology
AS2863619 free base enables conversion of antigen-specific effector/memory T cells into Foxp3 ⁺ regulatory T (T_reg) cells for the treatment of various immunological diseases. AS2863619 free base is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC₅₀s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 free base inhibition of CDK8/19, which consequently activates the Foxp3 gene .

HY-155505

AHR agonist 4	Aryl Hydrocarbon Receptor	Inflammation/Immunology
AHR agonist 4 (compound 24e) is an agonist of Aryl hydrocarbon receptor (AHR), assocaited with the immune balance of Th17/22 and Treg cells. AHR agonist 4 serves as a lead compound for anti-psoriasis drug, alleviates imiquimod (IMQ)-induced psoriasis-like skin lesion . AHR agonist 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-103637

Vimirogant VTP-43742	ROR	Inflammation/Immunology
Vimirogant (VTP-43742) is a potent, selective, and orally active RORγt inhibitor (K_i=3.5 nM; IC₅₀=17 nM). Vimirogant exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant inhibits Th17 differentiation and IL-17A secretion from mouse splenocytes (IC₅₀=57 nM) without affecting Th1, Th2, or Treg cell differentiation. Vimirogant has the potential for autoimmune disorders research .

HY-103637A

Vimirogant hydrochloride VTP-43742 hydrochloride	ROR	Inflammation/Immunology
Vimirogant (VTP-43742) hydrochloride is a potent, selective, and orally active RORγt inhibitor (K_i=3.5 nM; IC₅₀=17 nM). Vimirogant hydrochloride exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant hydrochloride inhibits Th17 differentiation and IL-17A secretion from mouse splenocytes (IC₅₀=57 nM) without affecting Th1, Th2, or Treg cell differentiation. Vimirogant hydrochloride has the potential for autoimmune disorders research .

Cat. No.	Product Name	Target	Research Area

HY-P1453A

CMD178 TFA	STAT	Cancer
CMD178 TFA is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits T_reg cell development .

HY-P2520

Influenza HA (110-119)	Influenza Virus	Inflammation/Immunology
Influenza HA (110-119) is the 110-119 fragment of influenza virus hemagglutinin that can stimulate Treg cells proliferation .

HY-P1453

CMD178

STAT Cancer

CMD178 is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits T_reg cell development .

CMD178	STAT	Cancer
CMD178 is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits T_reg cell development .

Cat. No.	Product Name	Target	Research Area

HY-P99327

Tregalizumab BT-061	Inhibitory Antibodies	Inflammation/Immunology
Tregalizumab is a humanized anti-human CD4 monoclonal antibody (IgG1 type) that selectively activates the suppressive properties of regulatory T cells (Tregs) in vitro. Tregalizumab can be used in the research of autoimmune diseases (resulting from insufficient Treg activity) and allergies .

HY-P990042

Gotistobart ONC-392; BNT 316	CTLA-4	Cancer
Gotistobart (ONC-392) is a humanized anti-CTLA-4 antibody that confers immunotherapeutic effect by selective depletion of regulatory T cells (Treg) in the tumor microenvironment .

HY-P990031

Dargistotug M-6223	Inhibitory Antibodies	Inflammation/Immunology Cancer
Dargistotug (M-6223) is a fully human IgG1 monoclonal antibody targeting TIGIT (T cell immune receptor with Ig domain and ITIM). TIGIT is an inhibitory immune checkpoint that promotes NK cell depletion and reduces the secretion of cytokines by binding to CD155 and other antibodies. It can also directly or indirectly inhibit effector T cells and upregulate Tregs cells, thereby exerting immunosuppression. Function .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0527

Pentagalloylglucose 5+ Cited Publications Penta-O-galloyl-β-D-glucose; 1,2,3,4,6-Pentagalloyl glucose	Infection Structural Classification other families Classification of Application Fields Anti-aging Source classification Phenols Polyphenols Plants Disease Research Fields	Parasite RABV
Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is a gallotannin isolated from various plants. It suppressed interleukin (IL)-4 induced signal pathway in B cell, and inhibited IgE production partially caused by increasing a population of Treg cells in conjunction with Treg-inducing factors. Pentagalloylglucose possesses significant anti-rabies virus (RABV) activity.

HY-125783

1-Palmitoyl-sn-glycero-3-phosphocholine	Infection Structural Classification Natural Products Classification of Application Fields Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
1-Palmitoyl-sn-glycero-3-phosphocholine is an abundant lysophosphatidylcholine. 1-Palmitoyl-sn-glycero-3-phosphocholine exhibits proinflammatory activity. 1-Palmitoyl-sn-glycero-3-phosphocholine can be used in the study of atherosclerosis .

HY-104026B

L-Kynurenine sulfate	Structural Classification Alkaloids Human Gut Microbiota Metabolites Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Aryl Hydrocarbon Receptor
L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype .

Cat. No.	Product Name	Chemical Structure

HY-B0172AS

Isoallolithocholic acid-d2
Isoallolithocholic acid-d₂ is the deuterium labeled Isoallolithocholic acid (HY-B0172A). Isoallolithocholic acid is a T cell regulator and enhances regulatory T cells (Tregs) differentiation[1][2].

HY-104026CS

L-Kynurenine-13C10 sulfate hemihydrate
L-Kynurenine- ¹³C10 (sulfate hemihydrate) is the ¹³C labeled L-Kynurenine sulfate. L-Kynurenine sulfate hemihydrate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype .

HY-104026BS

L-Kynurenine-13C10 sulfate
L-Kynurenine-13C10 (sulfate) is the 13C labeled L-Kynurenine sulfate. L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype .

Cat. No.	Product Name		Classification

HY-155505

AHR agonist 4		Alkynes
AHR agonist 4 (compound 24e) is an agonist of Aryl hydrocarbon receptor (AHR), assocaited with the immune balance of Th17/22 and Treg cells. AHR agonist 4 serves as a lead compound for anti-psoriasis drug, alleviates imiquimod (IMQ)-induced psoriasis-like skin lesion . AHR agonist 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Treg cells

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Natural
Products